UPDATE: I-70 reopened about 12 hours later.

GLENWOOD CANYON, Colo. (CBS4) – Eastbound Interstate 70 is closed in Glenwood Canyon due to a “major” crash that sent a westbound vehicle into the eastbound lanes on Friday afternoon. The Colorado State Patrol said the closure was expected to be in place overnight — or for at least 12 hours.

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(credit: Colorado Department of Transportation)

At least one vehicle was upside down and laying perpendicular to the lanes.

CSP Master Trooper Gary Cutler told CBS4 that a “semi pulling an RV” was involved, but could not be more specific.

An image posted by CDOT showed people standing outside their stopped vehicles behind the crash.

Trooper Cutler said one driver was transported to a Vail hospital. There was no word on that person’s condition.

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Cutler said another vehicle was struck by debris, but there were only only minor injuries to one person inside.

A HAZMAT team was deployed to deal with a small fuel leak from a saddle tank from one vehicle involved.

“Eastbound motorists are advised to take the northern alternate route between Rifle and Silverthorne, from CO 13 to US 40 to CO 9,” CDOT officials tweeted.

Around 4 p.m. on Friday, the closure was modified.

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Emergency officials tweeted, “I-70 is closed at mile-marker 87 EB, West Rifle, Existing closure has been moved from mile-marker 109. Local Traffic is able to get through.”

Anica Padilla