Sefo Liufau completed 31 of 46 passes for 278 yards and three touchdowns but the Buffaloes could not avoid their 15th consecutive loss to a ranked team.
The tricky task for Colorado (1-1) is finding a way to somehow stifle No. 16 Arizona State (2-0) in the Pac-12 opener for both schools on Saturday night.
Struggling on both sides of the ball against the fired-up Sun Devils, Colorado trailed by 25 points in the first quarter and never recovered in a 54-13 loss to Arizona State on Saturday night.
The Colorado Buffaloes are coming off their first bye week since Jon Embree took over the program two years ago. It may not help.